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However, some people taking semaglutide might experience mild dehydration

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Among participants who continued treatment and reached their maximum tolerated dose during the extension period, average weight loss approached 30% over a longer follow-up

This dual mechanism is why tirzepatide outperforms single-agonist GLP-1 medications in head-to-head comparisons

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Serious adverse events like acute pancreatitis or severe dehydration remain rare when patients follow provider guidance and stay hydrated